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Conversely, the ubiquitin ligase E3 HUWE1/MULE, which acts as a negative regulator of ferroptosis, regulates iron metabolism by targeting transferrin receptor 1 and counteracts abnormal iron accumulation, thereby alleviating acute liver injury caused by hepatic ischemia-reperfusion (I/R) [34]

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Using these differentially expressed metabolites as features, an integrated LCMS and machine learning (ML) approach demonstrated that a logistic regression (LR) model achieved optimal performance in classifying serum samples (AUC = 0.933), indicating its strong power to distinguish SLE from other autoimmune diseases (ADs) [45]

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Pharmaceutics 12, (2020), Reactant(s): Mouse, Abstract Cinnamaldehyde protects against oxidative stress and inhibits the TNFinduced inflammatory response in human umbilical vein endothelial cells.: Kim, N